The phage–bacteria arms race Phase separation-mediated condensate formation promotes organelle contacts Promoter proximal pausing of RNA polymerase across evolution Computation and deep-learning-driven advances in CRISPR genome editing Mechanism and reconstitution of circadian transcription in cyanobacteria Structural visualization of the molecular evolution of CRISPR–Cas9 Structure and mechanism of antiphage retron Eco2 Mitochondrial ligase MAPL drives pyroptotic cell death Cell-cycle-dependent repression of histone gene transcription by histone H4 A negative feedback mechanism controls histone gene expression High-resolution cryo-EM meets parasitology in structural models of the conoid from Toxoplasma Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry An anti-CRISPR targets the sgRNA to block Cas9 and guides the design of enhanced genome editors When cryo-EM modeling meets structure prediction ADAR1 is an editor of DNA replication forks Author Correction: Heterochromatin boundaries maintain centromere position, size and number Ribosome-associated quality control and related mechanisms Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis Checking in on proteostasis Identifying factors regulating tauopathies FAD-dependent stabilization of FSP1 promotes ferroptosis resistance PADI6 binds UBE2D and UHRF1 to control protein ubiquitination in oocytes A proteome-wide dependency map of protein interaction motifs A SLiM view of the human proteome Factors for a successful partnership between academia and industry Charting the 3D regulatory landscape of sex determination with geostatistics Function and regulation of the mitochondrial stress response The maternal PADI6–UHRF1–UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesis Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15 Zscan4 enables the formation of the Z compartment Integrator subunit INTS12 links ribotoxic stress to transcription-coupled nucleotide excision repair Author Correction: Structural basis for translational control by the human 48S initiation complex Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity Author Correction: Structure and mechanism of antiphage retron Eco2 Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs The AlphaGenome deep learning model predicts effects of non-coding variants Global reorganization of genome architecture at the transition to gametogenesis Core principles of autophagy initiation mechanisms Author Correction: Phosphorylation-dependent tuning of mRNA deadenylation rates Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex The filamentous ultrastructure of the PopZ condensate is required for its cellular function Closing 2025, and a look ahead The aging of the AlphaFold database Peer review for early career researchers Focus on ubiquitylation and protein degradation Structure-guided molecular glues: Proteostasis Reporting light microscopy data in our pages