The phage–bacteria arms race
Phase separation-mediated condensate formation promotes organelle contacts
Promoter proximal pausing of RNA polymerase across evolution
Computation and deep-learning-driven advances in CRISPR genome editing
Mechanism and reconstitution of circadian transcription in cyanobacteria
Structural visualization of the molecular evolution of CRISPR–Cas9
Structure and mechanism of antiphage retron Eco2
Mitochondrial ligase MAPL drives pyroptotic cell death
Cell-cycle-dependent repression of histone gene transcription by histone H4
A negative feedback mechanism controls histone gene expression
High-resolution cryo-EM meets parasitology in structural models of the conoid from Toxoplasma
Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription
Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
An anti-CRISPR targets the sgRNA to block Cas9 and guides the design of enhanced genome editors
When cryo-EM modeling meets structure prediction
ADAR1 is an editor of DNA replication forks
Author Correction: Heterochromatin boundaries maintain centromere position, size and number
Ribosome-associated quality control and related mechanisms
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
Checking in on proteostasis
Identifying factors regulating tauopathies
FAD-dependent stabilization of FSP1 promotes ferroptosis resistance
PADI6 binds UBE2D and UHRF1 to control protein ubiquitination in oocytes
A proteome-wide dependency map of protein interaction motifs
A SLiM view of the human proteome
Factors for a successful partnership between academia and industry
Charting the 3D regulatory landscape of sex determination with geostatistics
Function and regulation of the mitochondrial stress response
The maternal PADI6–UHRF1–UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesis
Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
Zscan4 enables the formation of the Z compartment
Integrator subunit INTS12 links ribotoxic stress to transcription-coupled nucleotide excision repair
Author Correction: Structural basis for translational control by the human 48S initiation complex
Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity
Author Correction: Structure and mechanism of antiphage retron Eco2
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs
The AlphaGenome deep learning model predicts effects of non-coding variants
Global reorganization of genome architecture at the transition to gametogenesis
Core principles of autophagy initiation mechanisms
Author Correction: Phosphorylation-dependent tuning of mRNA deadenylation rates
Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization
Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
The filamentous ultrastructure of the PopZ condensate is required for its cellular function
Closing 2025, and a look ahead
The aging of the AlphaFold database
Peer review for early career researchers
Focus on ubiquitylation and protein degradation
Structure-guided molecular glues: Proteostasis
Reporting light microscopy data in our pages