Journal & Article

Biological and Statistical Physics

I/F
# Journal I/F

NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial ligase MAPL drives pyroptotic cell death Cell-cycle-dependent repression of histone gene transcription by histone H4 A negative feedback mechanism controls histone gene expression High-resolution cryo-EM meets parasitology in structural models of the conoid from Toxoplasma Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry An anti-CRISPR targets the sgRNA to block Cas9 and guides the design of enhanced genome editors When cryo-EM modeling meets structure prediction ADAR1 is an editor of DNA replication forks Author Correction: Heterochromatin boundaries maintain centromere position, size and number Closing 2025, and a look ahead The aging of the AlphaFold database Peer review for early career researchers Focus on ubiquitylation and protein degradation Structure-guided molecular glues: Proteostasis Reporting light microscopy data in our pages Better SIFI than sorry: Stress signaling How we peer review structural data The importance of physiological and disease contexts in capturing mRNA modifications Timing of complex I activity and lifespan control: Aging Transcription stress causes an inflammatory response via release of IL-1α: Innate immunity A transcription coupling model for how enhancers communicate with their target genes Presenilins balancing autophagy and extracellular vesicle secretion: Autophagy Thylakoid membrane remodeling by VIPP1 ESCRT-III-like filaments: Membrane trafficking Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies From atoms to cells Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides The guanylate-binding protein GBP1 forms a protein coat that enwraps cytosol-invasive bacteria Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth Insights into phosphate homeostasis regulation by XPR1: Membrane proteins Targeted degradation of membrane proteins KIF1C activates and extends dynein movement through the FHF cargo adapter Molecular basis of human nuclear and mitochondrial tRNA 3′ processing Intronic variant increases Parkinson disease risk by disrupting branchpoint sequence ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage Importance of an N-terminal structural switch in the distinction between small RNA-bound and free ARGONAUTE Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications Capture, mutual inhibition and release mechanism for aPKC–Par6 and its multisite polarity substrate Lgl Interfacial water confers transcription factors with dinucleotide specificity Mechanism of mammalian transcriptional repression by noncoding RNA RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation Capturing eukaryotic ribosome dynamics in situ at high resolution DARPin-induced reactivation of p53 in HPV-positive cells Inherent asymmetry of Rpd3S coordinates its nucleosome engagement and association with elongating RNA polymerase II Structural basis of circularly permuted group II intron self-splicing Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring The conformational landscape of human transthyretin revealed by cryo-EM